Reliable ways to identify senescent cells represent a bottleneck for understanding the roles
of senescence in physiology and disease. This Comment examines the challenges of …

The contribution of cellular senescence to the aging of animals is still a controversial issue.
Human diploid fibroblasts can be cultured in vitro for a finite number of divisions, after which …

Cultured normal human and animal cells are predestined to undergo irreversible functional
decrements that mimic age changes in the whole organism. When normal human embryonic …

Aging is the main risk factor for many degenerative diseases and declining health.
Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction …

Cellular senescence is the dynamic process of durable cell-cycle arrest. Senescent cells
remain metabolically active and often acquire a distinctive bioactive secretory phenotype …

Somatic cells have a limited capacity to proliferate. They reach a state of permanent growth
arrest after a certain number of cell divisions. This irreversible cell cycle arrest was first …

The notion that there might be a cellular basis for aging stems from research that began
several decades ago and was proposed to explain the loss of proliferative homeostasis …

The field of research on cellular senescence experienced a rapid expansion from being
primarily focused on in vitro aspects of aging to the vast territories of animal and clinical …

Cellular senescence was traditionally considered a stress response that protected the
organism by limiting the proliferation of damaged and unwanted cells. However, the recent …

The idea that senescent cells are causally involved in aging has gained strong support from
findings that the removal of such cells alleviates many age‐related diseases and extends …