Renal 20-HETE inhibition attenuates changes in renal hemodynamics induced by l-NAME treatment in pregnant rats
H Huang, Y Zhou, VT Raju, J Du… - American Journal …, 2005 - journals.physiology.org
We previously reported that inhibition of nitric oxide (NO) synthesis by N-nitro-l-arginine
methyl ester (l-NAME) during late pregnancy leads to increased production of renal vascular …
methyl ester (l-NAME) during late pregnancy leads to increased production of renal vascular …
Regulation of renal CYP4A expression and 20-HETE synthesis by nitric oxide in pregnant rats
MH Wang, J Wang, HH Chang… - American Journal …, 2003 - journals.physiology.org
20-Hydroxyeicosatetraenoic acid (20-HETE), which promotes renal vasoconstriction, is
formed in the rat kidney primarily by cytochrome P-450 (CYP) 4A isoforms (4A1, 4A2, 4A3 …
formed in the rat kidney primarily by cytochrome P-450 (CYP) 4A isoforms (4A1, 4A2, 4A3 …
Cytochrome P-450 inhibition attenuates hypertension induced by reductions in uterine perfusion pressure in pregnant rats
MT Llinás, BT Alexander, MF Capparelli, MA Carroll… - …, 2004 - Am Heart Assoc
The present study tested the hypothesis that cytochrome P-450 (CYP) metabolites of
arachidonic acid (AA) are involved in mediating hypertension and renal vasoconstriction …
arachidonic acid (AA) are involved in mediating hypertension and renal vasoconstriction …
Inhibition of 20-HETE production contributes to the vascular responses to nitric oxide
M Alonso-Galicia, HA Drummond, KK Reddy… - …, 1997 - Am Heart Assoc
Nitric oxide (NO) inhibits a variety of heme-containing enzymes, including NO synthase and
cytochrome P4501A1 and 2B1. The present study examined whether NO inhibits the …
cytochrome P4501A1 and 2B1. The present study examined whether NO inhibits the …
Increases in renal medullary 20‐HETE formation oppose the development of hypertension and improves pressure natriuresis in CYP4A1 transgenic Dahl S rats
A genetic deficiency in renal 20‐HETE formation contributes to the development of
hypertension in Dahl (S) rats. We hypothesized upregulation of CYP4A protein expression …
hypertension in Dahl (S) rats. We hypothesized upregulation of CYP4A protein expression …
20-HETE and CYP4A2 ω-hydroxylase contribute to the elevated blood pressure in hyperandrogenemic female rats
In male rats, androgen supplements increase 20-hydroxyeicosatetraenoic acid (20-HETE)
via cytochrome P-450 (CYP) 4A ω-hydroxylase and cause an increase in blood pressure …
via cytochrome P-450 (CYP) 4A ω-hydroxylase and cause an increase in blood pressure …
20‐SOLA, a Novel Water Soluble 20‐HETE Antagonist, Reduces Blood Pressure Through Regulation of Vascular ACE Expression via an IKK Dependent Pathway
V Garcia, B Shkolnik, V Pandey, J Capdevila… - The FASEB …, 2015 - Wiley Online Library
Increased vascular 20‐HETE has been associated with hypertension and activation of the
renin‐angiotensin system through induction of vascular angiotensin converting enzyme …
renin‐angiotensin system through induction of vascular angiotensin converting enzyme …
Endothelial-specific CYP4A2 overexpression leads to renal injury and hypertension via increased production of 20-HETE
K Inoue, K Sodhi, N Puri, KH Gotlinger… - American Journal …, 2009 - journals.physiology.org
We have previously reported that adenoviral-mediated delivery of cytochrome P-450 (CYP)
4A2, which catalyzes the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE), results in …
4A2, which catalyzes the synthesis of 20-hydroxyeicosatetraenoic acid (20-HETE), results in …
The Blood Pressure–Lowering Effect of 20-HETE Blockade in Cyp4a14 (−/−) Mice Is Associated with Natriuresis
20-Hydroxy-5, 8, 11, 14-eicosatetraenoic acid (20-HETE) has been linked to pro-
hypertensive and anti-hypertensive actions through its ability to promote vasoconstriction …
hypertensive and anti-hypertensive actions through its ability to promote vasoconstriction …