Our previous studies in rodent models of nephropathy demonstrate that 2-hydroxyestradiol
(2HE), an estradiol metabolite with little estrogenic activity, exerts renoprotective effects. In …

Aims Current antihypertensive therapies cannot cure hypertension and a life-long
medication is necessary. Maternal treatment may represent a promising strategy for …

Preeclampsia (PE) is a hypertensive disorder of pregnancy afflicting 5‐10% of US
pregnancies. Recent data suggests the vasoactive cytochromeP450 metabolite, 20 …

New Findings• What is the central question of this study? Gestational hypertension is a
major obstetric problem of placental origin, associated with reduced production of 2 …

Background: Evidence suggests that estradiol offers protection against the development of
cardiovascular and renal pathologies, although the mechanisms involved are still under …

Background—Preeclampsia is a multisystem disorder of pregnancy, originating in the
placenta. Cytochrome P450 (CYP)-dependent eicosanoids regulate vascular function …

Pregnancy is a state of vasodilation mediated by nitric oxide (NO). This vasodilation is
impaired in women with preeclampsia, and an alteration in the L-arginine–NO pathway may …

The potent vasoactive lipid 20‐Hydroxyeicosatetraenoic acid (20‐HETE) exhibits a range of
bioactions across the vasculature including stimulation of endothelial dysfunction (ED) and …

Clinical data report an increase in adverse pregnancy outcomes in women with a history of
AKI despite clinical recovery prior to pregnancy. We developed a rat model of pregnancy …

Abstract Concentrations of 2-methoxyestradiol (2ME2), a principal metabolite of estradiol,
are significantly lower in women with severe preeclampsia. Nitric oxide (NO) released by …