Background: Cellular senescence and spontaneous differentiation are critical phenomena
that impair long-tern study of cells in vitro. The same problems are similarly encountered in …

Background: Cellular senescence and spontaneous differentiation are critical phenomena
that impair long-tern study of cells in vitro. The same problems are similarly encountered in …

To overcome loss of stem-like properties and spontaneous differentiation those hinder the
expansion and application of human mesenchymal stem cells (hMSCs), we have clonally …

Telomerase is expressed in adult mouse, but not in most human, tissues and mouse
telomeres are much longer than those in humans. This interspecies difference of telomere …

To investigate the effect of transfection of hTERT gene into human mesenchymal stem cells
MSCs on their telomerase activity and lifespan. METHODS Human MSCs were transfected …

Telomeres cap the ends of eukaryotic chromosomes, masking the end from DNA repair
processes and preventing end-to-end fusions. Telomeres shorten progressively with each …

Objectives: Previous studies have reported immortalization and tumorigenicity of human
mesenchymal stem cells (hMSCs) transduced with exogenous human telomerase reverse …

Background Telomerase deficiency has been associated with inadequate differentiation of
mesenchymal stem cells. However, the effect of telomerase deficiency on differential …

Multipotent mesenchymal stem cells (MSCs) are widely used as seed cells in studies of
tissue engineering and regenerative medicine; however, their clinical application is limited …

Human mesenchymal stem cells (hMSCs) are highly desirable cells for bone engineering
due to the inherent multipotent nature of the cells. Unfortunately, there is a high degree of …