Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Much of the population is now faced with an enormous burden of age-associated chronic
diseases. Recent discoveries in geroscience indicate that healthspan in model organisms …

Highlights•Senescent cells contribute to aging and age-related diseases.•Reducing the
secretory phenotype of senescent cells (SASP) has beneficial effects.•Elimination of …

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …

Recent discoveries are redefining our view of cellular senescence as a trigger of tissue
remodelling that acts during normal embryonic development and upon tissue damage. To …

Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

Life expectancy has increased substantially over the last few decades, leading to a
worldwide increase in the prevalence and burden of aging-associated diseases. Recent …

Cellular senescence, first observed and defined through cell culture studies, is a cell fate
associated with essentially permanent cell cycle arrest and that can be triggered by a variety …

The influence of the activation of a cellular phenotype termed senescence and it's
importance in ageing and age-related diseases is becoming more and more evident. In fact …