Telomerase is expressed in adult mouse, but not in most human, tissues and mouse
telomeres are much longer than those in humans. This interspecies difference of telomere …

Telomerase is tightly regulated in humans relative to mice, owing to the differential
regulation of TERT genes. To explore hTERT regulation in vivo, we engineered mice with a …

Mammalian telomerase is essential for the maintenance of telomere length [1–5]. Its catalytic
core comprises a reverse transcriptase component (TERT) and an RNA component. While …

The fundamental role of telomerase is to protect telomere ends and to maintain telomere
length during replication; hence, telomerase expression is high in stem cells but reduced …

Background Telomerase consists of two essential subunits, the template RNA (TR;
telomerase RNA) and the catalytic subunit TERT (telomerase reverse transcriptase) …

Here, we show that ectopic expression of the catalytic subunit of mouse telomerase (mTert)
confers a growth advantage to primary murine embryonic fibroblasts (MEFs), which have …

Background The reverse transcriptase of telomerase (Tert) controls telomerase activity
maintaining the end of linear chromosomes in eukaryotic cells. Telomerase function is highly …

Embryonic stem cells (ESC) are a unique cell population with the ability to self-renew and
differentiate into all three germ layers. Human ESC express the telomerase reverse …

Telomerase, the enzyme which maintains the ends of linear chromosomes in eukaryotic
cells, is found at low levels in somatic stem cells but while this is incapable of preventing the …

Telomerase, regulated primarily by the transcription of its catalytic subunit telomerase
reverse transcriptase (TERT), is critical for controlling cell proliferation and tissue …