Multipotent mesenchymal stem cells (MSCs) are widely used as seed cells in studies of
tissue engineering and regenerative medicine; however, their clinical application is limited …

Human mesenchymal stem cells (hMSCs) are highly desirable cells for bone engineering
due to the inherent multipotent nature of the cells. Unfortunately, there is a high degree of …

Mesenchymal stem cells (MSCs) represent one of the most promising stem cells for a
number of degenerative conditions due to their multipotency, immunoprivileged properties …

Human telomerase reverse transcriptase (hTERT), the essential catalytic subunit of
telomerase, is associated with telomere homeostasis to prevent replicative senescence and …

The contribution of deficient telomerase activity to age-related decline in osteoblast functions
and bone formation is poorly studied. We have previously demonstrated that telomerase …

Telomere shortening owing to telomerase deficiency leads to accelerated senescence of
human skeletal (mesenchymal) stem cells (MSCs) in vitro, whereas overexpression leads to …

In most clinical trials, human mesenchymal stem cells (hMSCs) are expanded in vitro before
implantation. The genetic stability of human stem cells is critical for their clinical use …

We have characterized and compared the telomere length, telomerase, reverse
transcriptase (RT) activity and expression of genes implicated in cancer and in pluripotency …

Background Telomerase deficiency has been associated with inadequate differentiation of
mesenchymal stem cells. However, the effect of telomerase deficiency on differential …

Human bone marrow mesenchymal stem cells (hMSC) represent a population of stem cells
that are capable of differentiation into multiple lineages. However, these cells exhibit …