[HTML][HTML] Genetic ablation of apolipoprotein A-IV accelerates Alzheimer's disease pathogenesis in a mouse model
The link between lipoprotein metabolism and Alzheimer's disease (AD) has been
established. Apolipoprotein A-IV (apoA-IV), a component of lipoprotein particles similar to …
established. Apolipoprotein A-IV (apoA-IV), a component of lipoprotein particles similar to …
Apolipoprotein E as vascular risk factor in neurodegenerative dementia.
M Folin, S Baiguera, MT Conconi… - International …, 2004 - spandidos-publications.com
Apolipoprotein E (ApoE) is the major lipid-carrier protein in the brain, and several studies
provided evidence that ApoE epsilon4 allele can be considered a genetic risk factor for …
provided evidence that ApoE epsilon4 allele can be considered a genetic risk factor for …
Apolipoprotein E, dementia and strokes
AD Korzcyn, J Chapman - Journal of the neurological sciences, 2003 - jns-journal.com
Ever since the association of the apolipoprotein E (APOE) q4 haplotypes with late-onset
Alzheimer's disease (AD) was identified [1], the interest in this ''modifying gene''effect has …
Alzheimer's disease (AD) was identified [1], the interest in this ''modifying gene''effect has …
Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid β peptides
T Tokuda, M CALERO, E MATSUBARA… - Biochemical …, 2000 - portlandpress.com
The inheritance of the apolipoprotein E (apoE) ϵ4 allele is a prevailing risk factor for
sporadic and familial Alzheimer's disease (AD). ApoE isoforms bind directly to Alzheimer's …
sporadic and familial Alzheimer's disease (AD). ApoE isoforms bind directly to Alzheimer's …
Characterization of transgenic mice expressing apolipoprotein E4 (C112R) and apolipoprotein E4 (L28P; C112R)
G Huber, W März, JR Martin, P Malherbe, JG Richards… - Neuroscience, 2000 - Elsevier
Apolipoprotein E (ApoE), which is genetically polymorphic, is a constituent of different
lipoproteins. Two variants, ApoE4 (C112R) and ApoE4 (L28P; C112R) have been linked to …
lipoproteins. Two variants, ApoE4 (C112R) and ApoE4 (L28P; C112R) have been linked to …
Characterization of apolipoprotein E-containing lipoproteins in cerebrospinal fluid: effect of phenotype on the distribution of apolipoprotein E
K Yamauchi, M Tozuka, H Hidaka, E Hidaka… - Clinical …, 1999 - academic.oup.com
Abstract Background: Apolipoprotein (apo) E, one of the main apolipoproteins in the central
nervous system, may play an important role in lipid metabolism; however, the details of its …
nervous system, may play an important role in lipid metabolism; however, the details of its …
Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different APOE genotypes
GW Rebeck, NC Alonzo, O Berezovska, SD Harr… - Experimental …, 1998 - Elsevier
Recent data have implicated apolipoprotein E (apoE) in neuritic outgrowth, synaptic stability,
and Alzheimer's disease; these data led us to examine the normal role of apoE-containing …
and Alzheimer's disease; these data led us to examine the normal role of apoE-containing …
C-terminal-truncated apolipoprotein (apo) E4 inefficiently clears amyloid-β (Aβ) and acts in concert with Aβ to elicit neuronal and behavioral deficits in mice
N Bien-Ly, Y Andrews-Zwilling, Q Xu… - Proceedings of the …, 2011 - National Acad Sciences
Apolipoprotein (apo) E4 is the major known genetic risk factor for Alzheimer's disease (AD).
We have shown in vitro and in vivo that apoE4 preferentially undergoes aberrant cleavage …
We have shown in vitro and in vivo that apoE4 preferentially undergoes aberrant cleavage …
Cerebrospinal fluid apolipoprotein E is reduced in Alzheimer's disease
K Blennow, C Hesse, P Fredman - Neuroreport, 1994 - journals.lww.com
APOLIPOPROTEIN E (ApoE) has been implicated in the pathogenesis of Alzheimer's
disease (AD). ApoE is synthesized within the brain and has been suggested to be involved …
disease (AD). ApoE is synthesized within the brain and has been suggested to be involved …