Aging is characterized by degeneration in cellular and organismal functions leading to
increased disease susceptibility and death. Although our understanding of aging biology in …

Summary Genome‐Wide Association studies (GWAS) offer an unbiased means to
understand the genetic basis of traits by identifying single nucleotide polymorphisms (SNPs) …

Longevity was influenced by many complex diseases and traits. However, the relationships
between human longevity and genetic risks of complex diseases were not broadly studied …

Microarray-based comparisons of long-lived and normal mouse strains represent a
promising approach for dissecting the basis of lifespan extension in higher organisms …

One way of testing possible causal relationships between various functional pathways and
aging and longevity processes is to comparatively analyze groups of elderly individuals with …

Genome‐wide and hypothesis‐based approaches to the study of ageing and longevity have
been dominated by genetic investigations. To identify essential mechanisms of a complex …

Copy number variations (CNVs) have been shown to cause numerous diseases, however,
their roles in human lifespan remain elusive. In this study, we investigate the association of …

The sequenced genomes of individuals aged≥ 80 years, who were highly educated, self-
referred volunteers and with no self-reported chronic diseases were compared to young …

Abstract The Open Genes database was created to enhance and simplify the search for
potential aging therapy targets. We collected data on 2402 genes associated with aging and …

Genetic studies have thus far identified a limited number of loci associated with human
longevity by applying age at death or survival up to advanced ages as phenotype. As an …