Significance: Aging is a complex trait that is influenced by a combination of genetic and
environmental factors. Although many cellular and physiological changes have been …

Aging is closely related to the occurrence of human diseases; however, its exact biological
mechanism is unclear. Advancements in high-throughput technology provide new …

Background Aging is a complex phenotype influenced by a combination of genetic and
environmental factors. Although many studies addressed its cellular and physiological age …

Organismal ageing results from interlinked molecular changes in multiple organs over time.
The study of ageing at the molecular level is complicated by varying decay characteristics …

Aging results in various deleterious changes in the human body that may lead to loss of
function and the manifestation of chronic diseases. While diseases can generally be reliably …

Organismal aging is driven by interconnected molecular changes encompassing internal
and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets …

Technical advancements over the past two decades have enabled the measurement of the
panoply of molecules of cells and tissues including transcriptomes, epigenomes …

Aging is a complex process. Transcriptomic studies of the last decade have identified genes
and pathways that are regulated during aging in multiple species and organs. Yet, since a …

Age is the strongest risk factor for many diseases including neurodegenerative disorders,
coronary heart disease, type 2 diabetes and cancer. Due to increasing life expectancy and …

Significance: Reductionist studies have contributed greatly to our understanding of the basic
biology of aging in recent years but we still do not understand fundamental mechanisms for …