Within cells or subcellular compartments misfolded and/or short-lived regulatory proteins are
degraded by protease machines, cage-forming multi-subunit assemblages. Their proteolytic …

Within cells or subcellular compartments misfolded and/or short-lived regulatory proteins are
degraded by protease machines, cage-forming multi-subunit assemblages. Their proteolytic …

Within cells or subcellular compartments misfolded and/or short-lived regulatory proteins are
degraded by protease machines, cage-forming multi-subunit assemblages. Their proteolytic …

Abstract'Chambered proteases', including the eukaryotic 26S proteasome, use the energy of
ATP to drive the unfolding and translocation of a polypeptide substrate into a chamber of …

Protein concentration in the cell is a function of the rates of protein synthesis and destruction,
and the regulation of both processes is necessary for a properly functioning cell. The …

Self-compartmentalizing proteases, such as the proteasome and several prokaryotic energy-
dependent proteases, are designed to act in the crowded environment of the cell. Proteins …

ATP-dependent proteases control the concentrations of hundreds of regulatory proteins and
remove damaged or misfolded proteins from cells. They select their substrates primarily by …

ATP-dependent proteases control diverse cellular processes by degrading specific
regulatory proteins. Recent work has shown that protein substrates are specifically …

The 7th General Meeting of the International Proteolysis Society (IPS2011) was held in San
Diego, California between 16th and 20th October, 2011. Approximately 300 delegates …

ATP dependent proteases are protein complexes that degrade intracellular proteins
involved in cell regulation and mediate protein quality control. In eukaryotes, the major ATP …