Aging is characterized by the interlocking decay of biological functions over time.
Microarrays have been successful in elucidating some of the genome-wide changes that …

Although studies over the last decades have firmly connected a number of genes and
molecular pathways to aging, the aging process as a whole still remains poorly understood …

A key goal of aging research was to understand mechanisms underlying healthy aging and
develop methods to promote the human healthspan. One approach is to identify gene …

By combining transcriptomic data with other data sources, inferences can be made about
functional changes during ageing. Thus, we conducted a meta-analysis on 127 publicly …

Gene expression alterations occurring with aging have been described for a multitude of
species, organs, and cell types. However, most of the underlying studies rely on static …

Aging is a complex process that can be characterized by functional and cognitive decline in
an individual. Aging can be assessed based on the functional capacity of vital organs and …

Background The biological mechanisms that underlie aging have not yet been fully
identified. Senescence, a phenomenon occurring in vitro, limits the number of cell divisions …

Aging is one of the most important biological processes and is a known risk factor for many
age-related diseases in human. Studying age-related transcriptomic changes in tissues …

Understanding the expression changes that come with age is an important step in
understanding the ageing process as a whole. By combining such transcriptomic data with …

To evaluate molecular events associated with the aging process in animal models and
human tissues, microarray analysis is performed at the regional and cellular levels to define …