Background The reverse transcriptase of telomerase (Tert) controls telomerase activity
maintaining the end of linear chromosomes in eukaryotic cells. Telomerase function is highly …

During the past several years increasing evidence indicating that the proliferation capacity of
mammalian cells is highly radiosensitive, regardless of the species and the tissue of origin of …

The human adult mesenchymal stem cell (hMSC) does not express telomerase and has
been shown to be the target for neoplastic transformation after transduction with hTERT …

Introduction: Currently, bone marrow-derived human mesenchymal stem cells (BM-hMSCs)
have been considered a standard source of hMSCs for research and clinical applications …

Leukemic stem cells that expressed endogenous telomerase activity were induced to show
overexpression of exogenous hTERT and were analyzed for biological changes in order to …

INTRODUCTION: Our previous experiments indicated that bone marrow mesenchymal stem
cells of rhesus monkey (RhBMSCs) have a low proliferative ability with a finite life span …

A study was conducted to develop a stable Vero cell line constitutively overexpressing
human telomerase reverse transcriptase (hTERT). The hTERT cDNA was obtained from the …

Most of normal human somatic cells can divide only a finite number of times and inevitably
become senescent. Telomerase is an enzyme that imparts replicative immortality by …

AIM: To study the telomere maintenance mechanism in mesenchymal stem calls (MSCs).
METHODS: MSCs were isolated from healthy human bone marrow by their adherence to …

Background: Human bone marrow stem cell (hBMSC) is a promising candidate in
regenerative medicine due to its plasticity and homing ability. However, in vitro survival and …