Objective: To study the telomerase activity changes during the differentiation of human
mesenchymal stem cells (MSCs) into adipocytes and the related mechanism. Methods …

During the process of immortalization, at least two mortality checkpoints, M1 and M2, must
be bypassed. Cells that have bypassed M1 (senescence) have an extended life span, but …

METHODS. Primary dermal fibroblasts from normal and AT individuals were used.
Amphotrophic retrovirus expressing hTERT was created with pMX-puro-hTERT in Phenix-A …

INTRODUCTION: To provide standard implemental cells for biomedical research, an
immortalized mesenchymal stem cell (MSC) lineage was established from the bone marrow …

RT-PCR and immunofluorescence assay showed that the expression levels of hTERT
mRNA and protein from Raji cells decreased with time after hTERT ASODN treatment. There …

BACKGROUND: Human telomerase reverse transcriptase (hTERT) is the first choice for
regulating the proliferation and directional differentiation, with multiple biological effects …

BACKGROUND: Studies have shown that human telomerase reverse transcriptase gene
(hTERT) transfection can significantly extend the life cycle of bone marrow mesenchymal …

Objective: To investigate the role of telomerase activation in aging by maintaining cultures of
hTRT-transduced human fetal lung fibroblasts. Methods: Following delivery of the hTRT …

Human adipose-derived adult stem cells (hADSCs) can express human telomerase reverse
transcriptase phenotypes under an appropriate culture condition. Because adipose tissue is …

Human bone marrow stromal cells (hBMSCs) are defined as pluripotent progenitor cells with
the ability to differentiate into osteoblasts, chondrochytes, adipocytes, muscle cells, and …