To establish an immortalized osteoblast cell line used for basal and clinical research of
orthopaedics. Human marrow stromal cells (hMSCs) had been inducted into osteoblasts …

BACKGROUND: Studies have shown that genetically modified Schwann cells can survive
for a longer time in vivo, and promote nerve regeneration and functional recovery …

Mouse telomerase reverse transcriptase (mTERT) is a gene that is expressed by cells that
need to continually divide without the characteristic shortening of telomeres that …

Background The reverse transcriptase of telomerase (Tert) controls telomerase activity
maintaining the end of linear chromosomes in eukaryotic cells. Telomerase function is highly …

BACKGROUND & OBJECTIVE: Telomerase has been thought to play an important role in
the carcinogenesis in recent years. Human telomerase reverse transcriptase (hTERT) is a …

Objective: To study the telomerase activity changes during the differentiation of human
mesenchymal stem cells (MSCs) into adipocytes and the related mechanism. Methods …

Most human somatic cells contain no or very low levels of telomerase. The over-expression
of the catalytic subunit (hTERT) of human telomerase is a common method to generate cells …

Loss of telomeric repeats has been causally linked to replicative senescence and aging in
human cells. In contrast to normal somatic cells, which are telomerase‐negative …

Changes in hTERT splice variant expression have been proposed to facilitate the decrease
of telomerase activity during fetal development in various human tissues. Here, we analyzed …

BACKGROUND: Normal stem cells usually express a low level of telomerase activity that
serves to stabilize the chromosomes during cell division and helps prevent cell senescence …