BACKGROUND: Studies have shown that genetically modified Schwann cells can survive
for a longer time in vivo, and promote nerve regeneration and functional recovery …

BACKGROUND & OBJECTIVE: Telomerase has been thought to play an important role in
the carcinogenesis in recent years. Human telomerase reverse transcriptase (hTERT) is a …

Loss of telomeric repeats has been causally linked to replicative senescence and aging in
human cells. In contrast to normal somatic cells, which are telomerase‐negative …

Changes in hTERT splice variant expression have been proposed to facilitate the decrease
of telomerase activity during fetal development in various human tissues. Here, we analyzed …

In proliferating normal and tumor cells, the telomere length (TL) is maintained by high
telomerase activity (TA). In the absence of TA the TL maintenance involves a mechanism of …

Abstract 4590 Introduction: Previously, we investigated 49 primary human glioblastoma cell
samples for expression of hTERT. 17 (35%) of them displayed hTERT gene expression and …

BACKGROUND: Telomerase reverse transcriptase (TERT) plays an important role in
telomerase activation. OBJECTIVE: To construct the targeting short hairpin RNA plasmid …

Purpose To introduce human telomerase reverse transcriptase (hTRT) into normal human
oral keratinocytes (OKC) to expand their life-span. Methods The pEGFP-hTRT was …

BACKGROUND: Normal stem cells usually express a low level of telomerase activity that
serves to stabilize the chromosomes during cell division and helps prevent cell senescence …

Objective To probe the activation mechanism of hTERT gene in cancer formation based on
cloning its upstream regulating region and observing the specific transcription activity in …