Basal levels of oxidants are indispensible for redox signaling to produce adaptive cellular
responses such as vitagenes linked to cell survival; however, at higher levels, they are …

It is well established that the risk to develop neurodegenerative disorders increases with
chronological aging. Accumulating studies contributed to characterize the age-dependent …

Aging researches have experienced an unprecedented advance over recent years. The
comprehension of process leading to age-associated alterations is at moment of the highest …

The accumulation of non-enzymatic modifications on both DNA and protein molecules under
the attack of reactive oxygen species (ROS), is one of the most possible factors responsible …

Aging is a gradual, complex process in which cells, tissues, organs, and the whole organism
itself deteriorate in a progressive and irreversible manner that, in the majority of cases …

Accumulation of oxidatively modified proteins is a hallmark of organismal aging in vivo and
of cellular replicative senescence in vitro. Failure of protein maintenance is a major …

Oxidatively modified proteins build-up with age results, at least in part, from the increase of
reactive oxygen species and other toxic compounds originating from both cellular …

Analogous to the term genomics, proteomics is defined as the analysis of the entire protein
complement expressed by a genome. However, proteomics is more diverse than genomics …

Proteins are major targets of reactive oxygen and nitrogen species (ROS/RNS) and
numerous post-translational, reversible or irreversible modifications have been …

Several studies demonstrated that oxidative damage is a characteristic feature of many
neurodegenerative diseases. The accumulation of oxidatively modified proteins may disrupt …