Cellular senescence is the arrest of normal cell division. Oncogenic genes and oxidative
stress, which cause genomic DNA damage and generation of reactive oxygen species, lead …

SnapShot: Cellular Senescence Pathways Page 1 See online version for legends and
references 816 Cell 170, August 10, 2017 © 2017 Elsevier Inc. DOI http://dx.doi.org/10.1016/j.cell.2017.07.049 …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

Cellular senescence is the state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …

Understanding the aging process and ways to manipulate it is of major importance for
biology and medicine. Among the many aging theories advanced over the years, the …

Cellular senescence is recognized as a critical cellular response to prolonged rounds of
replication and environmental stresses. Its defining characteristics are arrested cell-cycle …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a
consequence display a radically altered phenotype that is thought to impair tissue function …