Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells
subjected to different stresses. Senescence is, therefore, a cellular defense mechanism that …

Cellular senescence is the irreversible growth arrest of individual mitotic cells, which as a
consequence display a radically altered phenotype that is thought to impair tissue function …

Cellular senescence is an important mechanism for preventing the proliferation of potential
cancer cells. Recently, however, it has become apparent that this process entails more than …

Cellular senescence is a highly stable cell cycle arrest that is elicited in response to different
stresses. By imposing a growth arrest, senescence limits the replication of old or damaged …

Cellular senescence is a state of permanent growth arrest and is thought to play a pivotal
role in tumor suppression. Cellular senescence may play an important role in tumor …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

In normal tissue, cell division is carefully regulated to maintain the correct proliferative
balance. Abnormal cell division underlies many hypoproliferative and hyperproliferative …

Significance: Cell senescence was originally defined by an acute loss of replicative capacity
and thus believed to be restricted to proliferation-competent cells. More recently …

Cellular senescence is a state of stable cell cycle arrest arising in response to DNA and
mitochondrial damages. Senescent cells undergo morphological, structural and functional …

Cellular senescence is a state comprising an essentially irreversible proliferative arrest
combined with phenotypic changes and pronounced secretory activity. Although …