Overexpression of Oct4, a stemness gene encoding a transcription factor, has been reported
in several cancers. However, the mechanism by which Oct4 directs transcriptional program …

Octamer-binding transcription factor 4 (Oct4), a homeodomain transcription factor, is well
established as a master factor controlling the self-renewal and pluripotency of pluripotent …

Background Oct4 is a major transcription factor related to stem cell self-renewal and
differentiation. To fulfill its functions, it must be able to enter the nucleus and remain there to …

Defining master transcription factors governing somatic and cancer stem cell identity is an
important goal. Here we show that the Oct4 paralog Oct1, a transcription factor implicated in …

OCT4A is well established as a master transcription factor for pluripotent stem cell (PSC) self-
renewal and a pioneer factor for initiating somatic cell reprogramming, yet its presence and …

OCT4 is a major regulator of pluripotency which has several spliced variants and expressed
pseudogenes. Here, we are reporting the existence of two additional novel spliced variants …

OCT4, a member of the POU family of gene products, is an octamer motif-binding
transcription factor. As it is known to play a crucial role in cancer processes including …

Although Oct4 is known as a critical transcription factor involved in maintaining “stemness”,
its role in tumor metastasis is still controversial. Herein, we overexpressed and silenced Oct4 …

Recently, evidences show that cancer stem cells (CSCs) are a type of cancer cell group with
self-renewal and play a huge role in tumor recurrence, metastasis, and drug resistance …

Cancer stem cells (CSCs) are thought to drive uncontrolled tumor growth, and the existence
of CSCs has recently been proven by direct experimental evidence, including tracing cell …