Purpose This work is a summary of regeneration mechanisms and some important aspects
of cellular and molecular factors in regeneration, in addition to techniques that have been …

Limb/digit amputation is a common event in humans caused by trauma, medical illness, or
surgery. Although the loss of a digit is not lethal, it affects quality of life and imposes high …

Background The regenerative capacity of organisms declines throughout evolution, and
mammals lack the ability to regenerate limbs after injury. Past approaches to achieving …

Bone is a highly specialized connective tissue and has a rare quality as one of the few
tissues that can repair without a scar to regain pre-injury structure and function. Despite the …

Abstract The Holy Grail to address the clinical grand challenge of human limb loss is to
develop innovative strategies to regrow the amputated limb. The remarkable advances in …

The astonishing regenerative ability of the urodele amphibian limb has long been
investigated as the chief model for regeneration in vertebrates. The urodele limb responds to …

Limb loss due to traumatic injury or amputation is a major biomedical burden. Many
vertebrates exhibit the ability to form and pattern normal limbs during embryogenesis from …

Whenever the topic of re-growing human limbs is posed for discussion, it is often argued that
'if a newt can do it, then so can we'. This notion, albeit promising, is somewhat like watching …

While urodele amphibians (newts and salamanders) can regenerate limbs as adults, other
tetrapods (reptiles, birds and mammals) cannot and just undergo wound healing. In adult …

Development of methods to reawaken the semi‐dormant regenerative potential that lies
within adult human tissues would hold promise for the restoration of diseased or damaged …