Background: Cellular senescence and spontaneous differentiation are critical phenomena
that impair long-tern study of cells in vitro. The same problems are similarly encountered in …

Background: Cellular senescence and spontaneous differentiation are critical phenomena
that impair long-tern study of cells in vitro. The same problems are similarly encountered in …

To investigate the effect of transfection of hTERT gene into human mesenchymal stem cells
MSCs on their telomerase activity and lifespan. METHODS Human MSCs were transfected …

To overcome loss of stem-like properties and spontaneous differentiation those hinder the
expansion and application of human mesenchymal stem cells (hMSCs), we have clonally …

Telomerase is expressed in adult mouse, but not in most human, tissues and mouse
telomeres are much longer than those in humans. This interspecies difference of telomere …

Telomerase activity has been suggested to be critically involved in hematopoietic stem cell
(HSC) self-renewal. However, it has been unclear whether human HSCs have telomerase …

Purpose: Cellular senescence and spontaneous differentiation are critical phenomena that
impair long-term study of human mesenchymal stem cells (hMSCs) in vitro, despite its high …

Objective. To investigate how mesenchymal stem cell (MSC) telomerase activity and life
span changes after introducing the human telomerase reverse transcriptase (hTERT) gene …

Objectives: Previous studies have reported immortalization and tumorigenicity of human
mesenchymal stem cells (hMSCs) transduced with exogenous human telomerase reverse …

Human mesenchymal stem cells (hMSCs) are highly desirable cells for bone engineering
due to the inherent multipotent nature of the cells. Unfortunately, there is a high degree of …