Molecular basis of immortalization of human mesenchymal stem cells by combination of p53 knockdown and human telomerase reverse transcriptase overexpression

TM Liu, WM Ng, HS Tan, D Vinitha, Z Yang… - Stem cells and …, 2013 - liebertpub.com
Mesenchymal stem cells (MSCs) represent one of the most promising stem cells for a
number of degenerative conditions due to their multipotency, immunoprivileged properties …

Human Bone Marrow–Derived Mesenchymal Stem Cells Do Not Undergo Transformation after Long-term In vitro Culture and Do Not Exhibit Telomere Maintenance …

ME Bernardo, N Zaffaroni, F Novara, AM Cometa… - Cancer research, 2007 - AACR
Significant improvement in the understanding of mesenchymal stem cell (MSC) biology has
opened the way to their clinical use. However, concerns regarding the possibility that MSCs …

Expression of human telomerase reverse transcriptase mediates the senescence of mesenchymal stem cells through the PI3K/AKT signaling pathway

Q Zhao, XY Wang, XX Yu, YX Zhai… - International …, 2015 - spandidos-publications.com
Multipotent mesenchymal stem cells (MSCs) are widely used as seed cells in studies of
tissue engineering and regenerative medicine; however, their clinical application is limited …

In vitro senescence of rat mesenchymal stem cells is accompanied by downregulation of stemness-related and DNA damage repair genes

U Galderisi, H Helmbold, T Squillaro… - Stem cells and …, 2009 - liebertpub.com
Mesenchymal stem cells (MSCs) are of particular interest because they are being tested
using cell and gene therapies for a number of human diseases. MSCs represent a rare …

Clonal heterogeneity in differentiation potential of immortalized human mesenchymal stem cells

T Okamoto, T Aoyama, T Nakayama… - Biochemical and …, 2002 - Elsevier
Mesenchymal stem cells (MSCs) are bone marrow stroma-derived cells, which can
differentiate into several types of mesenchymal tissues. Although regarded as tissue-specific …

Maintenance of differentiation potential of human bone marrow mesenchymal stem cells immortalized by human telomerase reverse transcriptase gene despite of …

BM Abdallah, M Haack-Sørensen, JS Burns… - Biochemical and …, 2005 - Elsevier
Human bone marrow mesenchymal stem cells (hMSC) represent a population of stem cells
that are capable of differentiation into multiple lineages. However, these cells exhibit …

Generation and characterization of an immortalized human mesenchymal stromal cell line

M Skårn, P Noordhuis, MY Wang, M Veuger… - Stem cells and …, 2014 - liebertpub.com
Human mesenchymal stromal cells (hMSCs) show great potential for clinical and
experimental use due to their capacity to self-renew and differentiate into multiple …

Introducing a single‐cell‐derived human mesenchymal stem cell line expressing hTERT after lentiviral gene transfer

W Böcker, Z Yin, I Drosse, F Haasters… - Journal of cellular …, 2008 - Wiley Online Library
Human mesenchymal stem cells (hMSCs) can be readily isolated from bone marrow and
differentiate into multiple tissues, making them a promising target for future cell and gene …

The molecular signature of in vitro senescence in human mesenchymal stem cells

HB Noh, HJ Ahn, WJ Lee, KB Kwack, YD Kwon - Genes & Genomics, 2010 - Springer
We investigated the molecular characteristics of in vitro senescence in human bone marrow-
derived mesenchymal stem cells. After prolonged in vitro expansion, MSCs underwent …

Immortalizing mesenchymal stromal cells from aged donors while keeping their essential features

M Piñeiro-Ramil, R Castro-Viñuelas… - Stem Cells …, 2020 - Wiley Online Library
Human bone marrow‐derived mesenchymal stromal cells (MSCs) obtained from aged
patients are prone to senesce and diminish their differentiation potential, therefore limiting …