Serum-free mouse embryo (SFME) cells were established by D. Barnes et al., and are
known to be a neural stem cell line, which differentiate into astrocytes upon treatment with …

During brain development, neuronal and glial cells are generated from neural precursors on
a precise schedule involving steps of proliferation, fate commitment and differentiation. We …

We sought to construct the adenoviral vector carrying the gene encoding mouse telomerase
reverse transcriptase (mTERT), as well as detect its expression and effect on the …

It is necessary to expand human neural progenitor cells in vitro to obtain large numbers for
research purposes and cell transplantation. A potential obstacle to in vitro expansion …

The DNA repair enzyme telomerase maintains chromosome stability by ensuring that
telomeres regenerate each time the cell divides, protecting chromosome ends. During onset …

Embryonic stem (ES) cell is well known as a totipotent cell, which is derived from a blastcyst
and has potential to differentiate into every kind of somatic cell. ES cell bears self-renewal …

Embryonic stem cell (ESC) research gave rise to the possibility that stem cell therapy could
be used in the treatment of incurable diseases such as neurodegenerative disorders …

Objective. To investigate how mesenchymal stem cell (MSC) telomerase activity and life
span changes after introducing the human telomerase reverse transcriptase (hTERT) gene …

The ability of human embryonic stem cells (hESCs) to proliferate indefinitely is attributed to
its high telomerase activity and associated long telomere. However, factors regulating …

There is significant interest in the potential use of telomerase-immortalized cells in
transplantation to replace neurons lost to neurodegenerative diseases and other central …