" Active health" has been emphasized in" Healthy China 2030" in dealing with the
challenges of population aging, so the anti-aging strategies are requires to be more precise …

ABSTRACT BACKGROUND: While a large wealth of literature on aging pertains to in silico,
experimental, and predicted genes, many of those genes do not have validated phenotypic …

After a brief introduction to the background, significance and unique features of the
centenarian population in China, we describe the Chinese Longitudinal Healthy Longevity …

Human lifespan variation is mainly determined by environmental factors, whereas the
genetic contribution is 25–30% and expected to be polygenic. Two complementary fields go …

Recent advances in molecular and genetic epidemiology provide us with tools to explore the
genetic sources of the variability in humans' biological aging. Genome-wide association …

Background Genetic research on longevity has provided important insights into the
mechanism of aging and aging-related diseases. Pinpointing import genetic variants …

Only two genome-wide significant loci associated with longevity have been identified so far,
probably because of insufficient sample sizes of centenarians, whose genomes may harbor …

Aging is a universal biological process, but with great individual variability, where some
remain healthy throughout old age while others suffer from health problems and co …

The development of next-generation sequencing (NGS) technologies to study the genome,
the transcriptome, and the epigenome has revolutionized the research in all life sciences …

Aging is an inevitable biological phenomenon. The incidence of age related disorders
(ARDs) such as cardiovascular diseases, cancer, arthritis, dementia, osteoporosis, diabetes …