The ε4 allele of apolipoprotein E (apoE) is a genetic risk factor for Alzheimer's disease (AD).
In order to gain a better understanding of the molecular mechanisms by which apoE and …

The apolipoprotein E (apoE) genotype is an important genetic risk factor for Alzheimer's
disease (AD). In the central nervous system (CNS), most apoE is produced by astrocytes …

The ε4 allele of apolipoprotein E (apoE) is associated with increased risk for Alzheimer's
disease (AD) and poor outcome after brain injury. In the CNS, apoE is expressed by glia …

Composition of central nervous system lipoproteins affects the metabolism of lipoprotein
constituents within the brain. The ε4 allele of apolipoprotein E (apoE) is a risk factor for …

The genetic association between the E4 isoform of apolipoprotein E (apoE) and increased
risk for Alzheimer's disease (AD) has prompted interest in the neurobiology of apoE and the …

Although apolipoprotein (apo) E is synthesized in the brain primarily by astrocytes, neurons
in the central nervous system express apoE, albeit at lower levels than astrocytes, in …

The major apolipoproteins (apo) on human cerebrospinal fluid lipoproteins are apoA-I and
apoE. Given the association between inheritance of the ε4 allele of the apoE gene (APOE4) …

The frequency of the ε4 allele of apolipoprotein E (apoE) is increased in late‐onset and
sporadic forms of Alzheimer's disease (AD). ApoE also binds to β‐amyloid (Aβ) and both …

The ε4 allele of apolipoprotein E (apo E) is associated with an increased risk for developing
Alzheimer's disease (AD). This may be due to interactions between apo E and the amyloid-β …

Apolipoprotein E (apoE) is a plasma protein that regulates lipid transport and cholesterol
homeostasis. In humans, apoE occurs as 3 major isoforms (apoE2, E3, and E4). Genetic …