Senescence and quiescence are frequently used as interchangeable terms in the literature
unwittingly. Despite the fact that common molecules play role in decision of cell cycle arrest …

Significance: Cell senescence was originally defined by an acute loss of replicative capacity
and thus believed to be restricted to proliferation-competent cells. More recently …

The accumulation of 'senescent'cells has long been proposed to act as an ageing
mechanism. These cells display a radically altered transcriptome and degenerative …

Cellular senescence is a program activated by normal cells in response to various types of
stress. These include telomere uncapping, DNA damage, oxidative stress, oncogene activity …

Cellular senescence is a highly complex and programmed cellular state with diverse and, at
times, conflicting physiological and pathological roles across the lifespan of an organism …

The study of cellular senescence and proliferative lifespan is becoming increasingly
important because of the promises of autologous cell therapy, the need for model systems …

Cellular senescence is implicated in several pathological responses in the adult, with
important repercussions in tumor suppression, wound healing, and aging. Two studies by …

Understanding the aging process and ways to manipulate it is of major importance for
biology and medicine. Among the many aging theories advanced over the years, the …

Cellular senescence is a critical stress response program implicated in embryonic
development, wound healing, aging, and immunity, and it backs up apoptosis as an ultimate …

Cellular senescence is an important mechanism for preventing the proliferation of potential
cancer cells. Recently, however, it has become apparent that this process entails more than …