Background Oct4 is a major transcription factor related to stem cell self-renewal and
differentiation. To fulfill its functions, it must be able to enter the nucleus and remain there to …

Recent studies show that Karyopherin alpha 2 (KPNA2) is up-regulated in quite a number of
cancers and associated with poor prognosis. Here, we found that expression levels of …

Abstract Karyopherin subunit alpha-2 (KPNA2) is overexpressed in various human cancers
and is associated with cancer invasiveness and poor prognosis in patient. Nevertheless, the …

Purpose Karyopherin alpha 2 (KPNA2) has been reported as an oncogenic protein in
numerous human cancers and is currently considered a potential therapeutic target …

Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignant cancers
worldwide, with a poor 5-year prognosis. Karyopherin α 2 (KPNA2) is a nuclear membrane …

Hepatocellular carcinoma (HCC) is one of the most aggressive cancers worldwide.
Identification of the molecular mechanisms underlying the development and progression of …

Abstract Karyopherin alpha 2 (KPNA2), a member of the karyopherin family, has a central
role in nucleocytoplasmic transport and is overexpressed in many cancers. Our previous …

Overexpression of Oct4, a stemness gene encoding a transcription factor, has been reported
in several cancers. However, the mechanism by which Oct4 directs transcriptional program …

Purpose Angiogenesis is involved in many pathological and physiological processes and is
mainly driven by hypoxia. Karyopherin subunit alpha 2 (KPNA2), a member of the nuclear …

Abstract Karyopherin β1 (Kpnβ1), also known as importin-β, is part of the karyopherin
superfamily of nuclear transport proteins. Kpnβ1 is an oncogene that is overexpressed in …