Digit Regeneration in Mammals

LA Dawson, PP Schanes, C Dolan, P Ketcham… - Innovations in Molecular …, 2016 - Springer
The astonishing regenerative ability of the urodele amphibian limb has long been
investigated as the chief model for regeneration in vertebrates. The urodele limb responds to …

The strategy and method in modulating finger regeneration

Y Choi, C Cox, K Lally, Y Li - Regenerative Medicine, 2014 - Future Medicine
The tip of the human finger can regenerate if the amputation is distal to the nail bed, usually
in young children. Studies in regeneration of rodent digits have shown that regeneration …

Digit tip regeneration: merging regeneration biology with regenerative medicine

CP Dolan, LA Dawson… - Stem cells translational …, 2018 - academic.oup.com
Regeneration Biology is the study of organisms with endogenous regenerative abilities,
whereas Regenerative Medicine focuses on engineering solutions for human injuries that …

[HTML][HTML] Bone growth as the main determinant of mouse digit tip regeneration after amputation

LA Sensiate, H Marques-Souza - Scientific reports, 2019 - nature.com
Regeneration is classically demonstrated in mammals using mice digit tip. In this study, we
compared different amputation plans and show that distally amputated digits regrow with …

The mouse digit tip: from wound healing to regeneration

J Simkin, M Han, L Yu, M Yan, K Muneoka - Wound Regeneration and …, 2013 - Springer
A challenge to the study of regeneration is determining at what point the processes of wound
healing and regeneration diverge. The mouse displays level-specific regeneration …

Regenerative Engineering of a Limb: From Amputation to Regeneration

AA Abedini, F Hosseini, CT Laurencin - Regenerative Engineering and …, 2023 - Springer
Purpose This work is a summary of regeneration mechanisms and some important aspects
of cellular and molecular factors in regeneration, in addition to techniques that have been …

Lessons for adult fingertip regeneration: glimpses from basic research

A Roshan, I Grant - The Journal of hand surgery, 2012 - Elsevier
Understanding the mechanisms involved in limb and finger regeneration holds promise for
improving current treatment therapies. Recent animal studies have improved our …

Regeneration and repair of human digits and limbs: fact and fiction

SJ Shieh, TC Cheng - Regeneration, 2015 - Wiley Online Library
A variety of digit and limb repair and reconstruction methods have been used in different
clinical settings, but regeneration remains an item on every plastic surgeon's “wish list.” …

Initiation of limb regeneration: the critical steps for regenerative capacity

H Yokoyama - Development, growth & differentiation, 2008 - Wiley Online Library
While urodele amphibians (newts and salamanders) can regenerate limbs as adults, other
tetrapods (reptiles, birds and mammals) cannot and just undergo wound healing. In adult …

The molecular basis of amphibian limb regeneration: integrating the old with the new

DM Gardiner, T Endo, SV Bryant - Seminars in cell & developmental biology, 2002 - Elsevier
Is regeneration close to revealing its secrets? Rapid advances in technology and genomic
information, coupled with several useful models to dissect regeneration, suggest that we …