Genetic factors contribute to human aging and longevity through the modulation of biologic
pathways, but few longevity-gene associations have been replicated to date. Participants in …

Longevity, ie, the property of being long-lived, has its natural limitation in the aging process.
Longevity has a strong genetic component, as has become apparent from studies with a …

Given the rising rate of survival into advanced old age in the United States, achieving
longevity and healthy aging is becoming increasingly important. Besides maintaining …

The Longevity Consortium is a multi-investigator, multi-institutional research group focused
on identifying the genetic variants that regulate human lifespan and healthy aging. The text …

There is an intense search for longevity genes in both animal models and humans. Human
family studies have indicated that a modest amount of the overall variation in adult lifespan …

An aging population of humans reflects early‐onset morbidity and mortality as well as late‐
onset disease in the phase when the mortality rate doubles and, finally, longevity of …

Research into the genetic component of human longevity can provide important insights in
mechanisms that may protect against age-related diseases and multi-morbidity. Thus far …

Introduction: Life expectancy and the rate of survival into old age have risen dramatically
throughout the past century. The positive ageing outcomes may be due to a variety of factors …

Once thought to be an extremely complex conundrum of weak genetic and environmental
effects, exceptional longevity is beginning to yield genetic findings. Numerous lower …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …