[HTML][HTML] Causes, effects, and constraints in the genetics of human longevity

F Schächter - The American Journal of Human Genetics, 1998 - cell.com
Jeanne Calment, who died recently in her 123d year, being the oldest human being alive on
earth, epitomized our quest for longevity. This deeply rooted quest has been spurred by …

Genes of aging

P Hamet, J Tremblay - Metabolism, 2003 - Elsevier
According to developmental genetics theories, aging is a genetically programmed and
controlled continuum of development and maturation. Being dynamic and malleable …

Genes, ageing and longevity in humans: problems, advantages and perspectives

S Salvioli, F Olivieri, F Marchegiani… - Free Radical …, 2006 - Taylor & Francis
Many epidemiological data indicate the presence of a strong familial component of longevity
that is largely determined by genetics, and a number of possible associations between …

The genetics of aging–implications for pharmacogenomics

T Perls, A Puca - Pharmacogenomics, 2002 - Taylor & Francis
Lifespan experiments of lower organisms and mammals along with recent studies of
centenarians are making inroads into delineating genetic factors that determine the ability to …

Frontiers of aging

GM Martin - Science, 2001 - science.org
After a long and sometimes painful incubation period, biochemical research on aging has
done what we all do eventually: It's come of age. The goal of the field is a deeper …

The human life span

MJ Moore - The Elderly as Modern Pioneers, ed. P Silverman, 1987 - books.google.com
At first glance, the term life span appears to be a relatively simple concept-how long an
individual lives from birth to death. However, there are several ways to view life span. When …

Unravelling genetic components of longevity

MR Jabalameli, ZD Zhang - Nature Aging, 2022 - nature.com
Many aging-related traits share a common genetic component. How to disentangle it from
trait-specific effects has remained largely unexplored. A new study in Nature Aging uses an …

Genetics of human longevity: From variants to genes to pathways

L Smulders, J Deelen - Journal of Internal Medicine, 2024 - Wiley Online Library
The current increase in lifespan without an equivalent increase in healthspan poses a grave
challenge to the healthcare system and a severe burden on society. However, some …

Unraveling genetic origin of aging-related traits: evolving concepts

AM Kulminski - Rejuvenation research, 2013 - liebertpub.com
Discovering the genetic origin of aging-related traits could greatly advance strategies aiming
to extend health span. The results of genome-wide association studies (GWAS) addressing …

Aging and longevity: towards the next millennium

GM Martin, E Wang - Molecular Medicine Today, 1998 - cell.com
Aging and longevity: towards the next millennium: Molecular Medicine Today Skip to Main
Content Advertisement Trends in Molecular Medicine This journal offers authors two options …