Ample evidence from model organisms has indicated that subtle variation in genes can
dramatically influence lifespan. The key genes and molecular pathways that have been …

Understanding the genetic basis of human longevity remains a challenge but could lead to
life-extending interventions and better treatments for age-related diseases. Toward this end …

This century has seen a proliferation of theories attempting to explain the nature of aging.
This can be partly explained by the growing interest in gerontological research and also as a …

Although thought previously had been given to the number and nature of the genes that are
inportant in aging, the beginning of genetic research on aging began in the early 1980s …

The sequencing of the human genome and the growing understanding of its function are
providing powerful new research tools for identifying genetic variants that are associated …

Human life expectancy has increased dramatically through improvements in public health,
housing, nutrition and general living standards. Lifespan is now limited chiefly by intrinsic …

There is no aging program, nor is there an aging gene. Instead, we age because evolution
has no reason to protect us against unwelcome actions of multiple genes late in life. Still …

Genome‐wide and hypothesis‐based approaches to the study of ageing and longevity have
been dominated by genetic investigations. To identify essential mechanisms of a complex …

Ageing is generally viewed as a detrimental phenotype; with age comes increasing
susceptibility to disease and frailty. Recent data also suggests that disease can result in an …

Variation in human aging and longevity has intrigued human biologists since Raymond
Pearl's landmark studies on the inheritance of lifespan (Pearl, 1922; Pearl and Pearl, 1934) …