Background: Recent studies investigating longevity have revealed very few convincing
genetic associations with increased lifespan. This is, in part, due to the complexity of …

Genetic factors contribute to human aging and longevity through the modulation of biologic
pathways, but few longevity-gene associations have been replicated to date. Participants in …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

Studies of long-lived individuals have revealed few genetic mechanisms for protection
against age-associated disease. Therefore, we pursued genome sequencing of a related …

The genetics of aging has seen extraordinary progress over the last few decades, with
animal models suggesting key roles for a number of metabolic pathways. However, humans …

Genetic studies have bestowed insight into the biological mechanisms underlying inter-
individual differences in susceptibility to (or resistance to) organisms' aging. Recent …

Many aging-related traits share a common genetic component. How to disentangle it from
trait-specific effects has remained largely unexplored. A new study in Nature Aging uses an …

Clear evidence exists for heritability of human longevity, and much interest is focused on
identifying genes associated with longer lives. To identify such longevity alleles, we …

In this review, we address the genetic continuum between aging and age-related diseases,
with particular attention to the ecological perspective. We describe the connections between …

Individuals who live to 85 and beyond without developing major age-related diseases may
achieve this, in part, by lacking disease susceptibility factors, or by possessing resistance …