… Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is
… by the virus. One possible theory is the invasion of SARS-CoV-2 to the brain occurs either …

… reported in acute and chronic phases of COVID-19 aflecting the frontal lobe of the brain. …
SARSCoV-2 invasion as a port of central nervous system entry in individuals with COVID-19. …

… pathway in which SARS-CoV2-infected immune cells cross the blood-brain barrier (BBB) via
… also suggested as an entry point for SARSCoV-2 invasion (Pacheco-Herrero et al., 2021). …

… Moriguchi 等 [5] 报道了第1 例与SARSCoV-2 相关的脑炎病例, 该… Brain invasion by mouse
hepatitis virus depends on impairment of tight junctions and beta interferon production in brain …

… Nonetheless, several authors have proposed theories about a possible neurotropism of
SARS-CoV-2 and a possible direct invasion of the brain by the virus, which could remain within …

… A number of studies have also shown that after SARSCoV-2 … The detection of viral copies
by SARS-CoV-2specific qPCR … in the brain stem, which supported the hypothesis that the virus …

… system, microglia in the brain, and many epithelial cells to facilitate pathogen recognition. …
adaptive responses to viral invasion. However, SARS-CoV-2 encodes many virulence factors …

… 自2020年3月日本报道首例COVID-19相关脑炎 ［2］ 后，COVID-19神经系统并发症报道增多
，成人病例主要表现为非特异性头痛、意识不清、头晕和脑卒中等 ［3-4］ 。脑炎、急性播散性脑脊髓炎…

… Elevation of ACE2 as a SARS⁃CoV⁃2 entry receptor gene … the brain in a patient with
coronavirus disease 2019(COVID⁃19) … Unravelingthe possible routes of SARS⁃COV⁃2 invasion …

… cortex; and reduced global brain size in the SARSCoV-2 cases compared to controls. These
… Beta-coronaviruses including SARS-CoV-2 are thought to invade the CNS by binding their …