… target the underlying mechanisms of AD. Here, we propose a class of nuclear receptors as
novel and promising new therapeutic targets for AD. This review summarizes the literature on …

… 'orphan' nuclear receptors for which … that nuclear receptors accomplish this role in close
collaboration with coregulators, which are integral to the mechanisms by which nuclear receptors …

… activation of nuclear receptors. More specific and potent nuclear receptor ligands are currently
being developed. This article will review the current knowledge on nuclear receptors and …

… However, RXR serves as a preferable heterodimerization partner for RAR, VDR, PPAR,
and some orphan receptors [6]. Nuclear receptor responsive elements share a conservative …

… nuclear factor-4; RXR-α, -β and -γ; testicular receptor, human homologue of the Drosophila
tailless gene/photoreceptor cell-specific nuclear receptor … the most relevant therapeutic target. …

… Among nuclear receptors (NRs), the orphan NR4A subfamily, … therapeutic target for the
treatment of inflammation. Areas covered: This review focuses on the capacity of NR4A receptors …

… therapies. Several lines of evidence support a putative therapeutic role of nuclear receptors
(… We discuss the failure in the translation of NR-based therapeutic approaches and consider …

Nuclear receptors (NR) are ligand-modulated transcription factors that play diverse roles in
cell differentiation, development, proliferation, and metabolism and are associated with …

… nuclear receptors, which when dysregulated are often linked to diseases. Because most
nuclear receptors … molecules, they are prominent therapeutic targets. The basic understanding …

Nuclear receptors (NRs) are ideal targets for drug discovery. Not only do they control a
myriad of biological and disease processes, but they are also regulated by small lipophilic …