… perspective focuses on whether Sig-2R is useful as a therapeutic target for CNS disorders
such as Alzheimer’s disease, Parkinson’s disease… Conclusion and future perspectives: Sig-2R …

… disease (AD), Parkinson’s disease (PD) and amyotrophic lateral sclerosis, among others (Tenreiro
et al., 2014; Chiti and Dobson, 2017). In this perspective… current and future therapeutic …

… repair, as well as the future perspectives. Overall, collagen is a … disease, or infusion of
phagocytic cells to eliminate beta-amyloid plaques. In Parkinson’s disease application of glial cell …

… This perspective seeks to elucidate this relationship and its implications for … novel approach
to Parkinson’s disease treatment with a potentially dual-acting therapeutic agent that targets α…

… The administration of high doses of thiamine to patients with PD was effective in reversing
the parkinsonian symptoms; we then suppose that the parenteral thiamine supplementation …

… factors for cell therapy in Parkinson’s disease is the low survival rate of grafted dopaminergic
cells. Different factors could cause cell death of … Conclusions and Future Perspectives …

… disease, where compromised BBB allowed entry of circulatory Aβ to the brain and, 2) Parkinson’s
disease… to the severity of the disease. Exosomes are reported to cross BBB and help in …

… disease and Parkinson’s disease. On the other hand, biological effects resulting from
neurodegeneration can in turn affect mitochondrial health and function, promoting a feedback loop …

… approaches spanning from stem cell-based cell therapy to extracellular vesicles such as …
future perspectives regarding the neural regeneration in the context of Huntington’s disease…

… of ALS and should be a target of future therapeutics. … Future research should focus on the
role of the NVU in neurological disease in order to design more targeted and novel therapies…