Characterizing sleep spindles in 11,630 individuals from the National Sleep Research Resource
Sleep spindles are characteristic electroencephalogram (EEG) signatures of stage 2 non-
rapid eye movement sleep. Implicated in sleep regulation and cognitive functioning,
spindles may represent heritable biomarkers of neuropsychiatric disease. Here we
characterize spindles in 11,630 individuals aged 4 to 97 years, as a prelude to future genetic
studies. Spindle properties are highly reliable but exhibit distinct developmental trajectories.
Across the night, we observe complex patterns of age-and frequency-dependent dynamics …
rapid eye movement sleep. Implicated in sleep regulation and cognitive functioning,
spindles may represent heritable biomarkers of neuropsychiatric disease. Here we
characterize spindles in 11,630 individuals aged 4 to 97 years, as a prelude to future genetic
studies. Spindle properties are highly reliable but exhibit distinct developmental trajectories.
Across the night, we observe complex patterns of age-and frequency-dependent dynamics …
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