[HTML][HTML] Entorhinal principal neurons mediate brain-stimulation treatments for epilepsy
Brain stimulation is an alternative treatment for epilepsy. However, the neuronal circuits
underlying its mechanisms remain obscure. We found that optogenetic activation (1Hz) of
entorhinal calcium/calmodulin-dependent protein kinase II α (CaMKIIα)-positive neurons, but
not GABAergic neurons, retarded hippocampal epileptogenesis and reduced hippocampal
seizure severity, similar to that of entorhinal low-frequency electrical stimulation (LFES).
Optogenetic inhibition of entorhinal CaMKIIα-positive neurons blocked the antiepileptic …
underlying its mechanisms remain obscure. We found that optogenetic activation (1Hz) of
entorhinal calcium/calmodulin-dependent protein kinase II α (CaMKIIα)-positive neurons, but
not GABAergic neurons, retarded hippocampal epileptogenesis and reduced hippocampal
seizure severity, similar to that of entorhinal low-frequency electrical stimulation (LFES).
Optogenetic inhibition of entorhinal CaMKIIα-positive neurons blocked the antiepileptic …
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