参与P-gp 膜定位和功能调控的相关蛋白研究进展

吴桐, 刘晓东 - 药学进展, 2021 - pps.cpu.edu.cn
… [Abstract] P-glycoprotein (P-gp), as a member of the ABC transporter family, possesses the
function of pumping drugsfunction and expression of P-glycoprotein and Mrp2 at the blood- …

溃疡性结肠炎患者肠黏膜P 糖蛋白的表达及其临床意义

付振美, 马铭泽 - 山东大学学报(医学版), 2020 - yxbwk.njournal.sdu.edu.cn
… Conclusion The impaired intestinal barrier and increased intestinal permeability in UC … of
P-glycoprotein in the colonic mucosa of ulcerative colitis patients and its clinical significance[J]. …

[HTML][HTML] 小檗碱的药理活性以及提升其口服生物利用度的策略

周剑雄, 吴送姑, 龚俊波, 魏振平 - 药学学报, 2022 - html.rhhz.net
… 下自聚集导致的溶解度差,渗透性低,P-gp (P-glycoprotein) 介导的外排和肝肠代谢.提高小檗碱的
… permeability, P-glycoprotein (P-gp)-mediated efflux, and liver and intestine metabolism. To …

天然产物用于癌症化学预防的口服生物利用度问题

郜嵩, 杨广义, 胡明 - 化学进展, 2013 - manu56.magtech.com.cn
metabolism are the primary factors that limit the oral bioavailability of these natural products
although chemical and microbial stability may also contributeP-glycoprotein (P-gp). Human …

CYP3A4 和P 糖蛋白与药物的肠道处置

辛华雯 - 中国临床药理学与治疗学, 2005 - manu41.magtech.com.cn
… P-gly coprotein expression and function in humans[ J] .Adv … The drug transporter P-glycoprotein
limits oral absorption and … modulation of intestinal CYP3A metabolism by P-glycoprotein :…

丙磺舒对大鼠体内头孢克罗药动学的影响

张秀红, 马张庆, 桂常青, 宋建国 - 中国临床药理学与治疗学 - manu41.magtech.com.cn
… Low limit detection of cefaclor was 0 .1 mg·L -1 as a signal to … [ 12] , organic cation transport
system [ 14] and P-glycoprotein-… :a mechanism contributing to poor oral absorption[ J] .…

多药耐药蛋白和CYP3A4 介导的中草药-西药相互作用

毛晓琴, 谢海棠, 周宏灏 - 中国临床药理学与治疗学, 2007 - manu41.magtech.com.cn
… oral bioavailability and CNS accumulation of drugs[ J] .Int J … The drug transporter P-glycoprotein
limits oral absorption and … induces intestinal P-glycoprotein MDR1 and intestinal and he…

重新定位二肽基肽酶4 抑制剂和胰升糖素样肽1 受体激动剂作为潜在的神经保护剂

SA Mousa, BM Ayoub - 中国神经再生研究(英文版), 2019 - sjzsyj.com.cn
… for P-glycoprotein, which not only limits the oral absorption … of cognition and neuronal function
in brain. Neurodegenerative … Author contributions: All authors have equally contributed to …

[PDF][PDF] Labrasol 对紫杉醇经大鼠小肠定位吸收的影响

李国锋, 任非, 许重远, 刘思佳, 刘佳… - 中国药学 …, 2009 - journal11.magtechjournal.com
Functional role of p-glycoprotein in limiting intestinal absorption of drugs: contribution of
passive permeability to p-glycoprotein-mediated efflux transport[J]. Mol Pharm, 2005, 2(1): 12-21…

联用丙磺舒对头孢克洛药动学的影响

栾家杰, 马张庆, 汪五三, 桂常青… - … 临床药理学与治疗学, 2006 - manu41.magtech.com.cn
… Detectable limit of cefaclorwas 0 .1 mg·L … , Na +-phosphate transporter1 (NPT1) and P-glycoprotein
( P-gP) mediated … compounds :a mechanism contributing to poor oral absorption[ J] .J …