[HTML][HTML] Impaired renal function and dysbiosis of gut microbiota contribute to increased trimethylamine-N-oxide in chronic kidney disease patients
KY Xu, GH Xia, JQ Lu, MX Chen, X Zhen, S Wang… - Scientific reports, 2017 - nature.com
Chronic kidney disease (CKD) patients have an increased risk of cardiovascular diseases
(CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine-
N-oxide concentration (TMAO) in Chinese CKD patients and explore the underlying
explanations through the animal experiment. The median plasma TMAO level was 30.33
μmol/L in the CKD patients, which was significantly higher than the 2.08 μmol/L
concentration measured in the healthy controls. Next-generation sequence revealed …
(CVDs). The present study aimed to investigate the gut microbiota and blood trimethylamine-
N-oxide concentration (TMAO) in Chinese CKD patients and explore the underlying
explanations through the animal experiment. The median plasma TMAO level was 30.33
μmol/L in the CKD patients, which was significantly higher than the 2.08 μmol/L
concentration measured in the healthy controls. Next-generation sequence revealed …
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