risk of kidney stones, we conducted a genome-wide association study in 3,773 cases and
42,510 controls from Iceland and The Netherlands. We discovered common, synonymous
variants in the CLDN14 gene that associate with kidney stones (OR= 1.25 and P= 4.0× 10−
12 for rs219780 [C]). Approximately 62% of the general population is homozygous for
rs219780 [C] and is estimated to have 1.64 times greater risk of developing the disease …