… converting enzymeinhibitors shifted the balance of treatment modalities towards enzyme inhibitors … Therefore, careful, quantitative assessment of compound interactions with metabolic …
E Mons, S Roet, RQ Kim, MPC Mulder - Current protocols, 2022 - Wiley Online Library
… the effects of in vitro enzyme activity assay conditions and inhibitor binding mode, thereby … to assess the biochemical potency of (ir)reversible covalent enzymeinhibitors targeting a …
A Dmitriev, D Filimonov, A Lagunin, D Karasev… - Molecules, 2019 - mdpi.com
… inhibiting and/or inducing the metabolism or transporter-mediated disposition of the victim drug. Accurate assessment … A comprehensive description of the methods for DDIs prediction is …
… MAKING BEST USE OF THE INHIBITOR INDEX – Experiments with enzymeinhibitors and receptor antagonists are least ambiguous when researchers maximize target specificity/…
… analyzed in this study that inhibited both enzymes, AChE and BChE. At 500 µM, IMZ inhibited AChE activity by about 48%, being this the higher inhibition value obtained (Figure 3A). As …
J Li, H Chang, N Zhang, Y He, D Zhang, B Liu, Y Fang - Talanta, 2023 - Elsevier
… and detection of enzymaticinhibitors owing to their low-cost, … a comprehensive overview of the current status of enzyme … of DON and BER to inhibit AChE being assessed through the …
G Kriszta, Z Kriszta, S Vancsa, PJ Hegyi… - Frontiers in …, 2021 - frontiersin.org
… Three studies assessed the influence of RAS inhibitors on ACE2 expression under physiological conditions. Following 12-days long oral administration, lisinopril or losartan elevated …
C Säll, JB Houston, A Galetin - Drug Metabolism and Disposition, 2012 - ASPET
… Involvement of aldehyde oxidase and aldehyde dehydrogenase in the second formation step of M2 was investigated by assessing the effect of known inhibitors of these enzymes, …
VW Byrnes, VV Sardana, WA Schleif… - Antimicrobial agents …, 1993 - Am Soc Microbiol
… assessments of mutant virus than thoseof mutant enzyme (… inhibitor interacts in a unique way with the enzyme'sinhibitor-… profiles established for each individual inhibitor may help in …