Circulating monocytes expressing senescence‐associated features are enriched in COVID‐19 patients with severe disease

Y Lin, DF Postma, LS Steeneken… - Aging …, 2023 - Wiley Online Library
Accurate biomarkers for predicting COVID‐19 severity have remained an unmet need due to
an incomplete understanding of virus pathogenesis and heterogeneity among patients …

Cellular senescence as a potential mediator of COVID‐19 severity in the elderly

J Nehme, M Borghesan, S Mackedenski, TG Bird… - Aging cell, 2020 - Wiley Online Library
SARS‐CoV‐2 is a novel betacoronavirus which infects the lower respiratory tract and can
cause coronavirus disease 2019 (COVID‐19), a complex respiratory distress syndrome …

[HTML][HTML] COVID-19 and cellular senescence

CA Schmitt, T Tchkonia, LJ Niedernhofer… - Nature Reviews …, 2023 - nature.com
The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …

[HTML][HTML] SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

S Tsuji, S Minami, R Hashimoto, Y Konishi, T Suzuki… - Nature aging, 2022 - nature.com
Reports of post-acute COVID-19 syndrome, in which the inflammatory response persists
even after SARS-CoV-2 has disappeared, are increasing, but the underlying mechanisms of …

[HTML][HTML] Pulmonary infection by SARS-CoV-2 induces senescence accompanied by an inflammatory phenotype in severe COVID-19: possible implications for viral …

K Evangelou, D Veroutis, K Paschalaki… - European …, 2022 - Eur Respiratory Soc
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of
the respiratory system can progress to a multisystemic disease with aberrant inflammatory …

[HTML][HTML] Role of senescence and aging in SARS-CoV-2 infection and COVID-19 disease

SM Lynch, G Guo, DS Gibson, AJ Bjourson, TS Rai - Cells, 2021 - mdpi.com
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), has resulted in a global pandemic associated with substantial …

Circulating biomarkers of inflammaging as potential predictors of COVID-19 severe outcomes

J Sabbatinelli, G Matacchione, A Giuliani… - Mechanisms of Ageing …, 2022 - Elsevier
The COVID-19 pandemic caused by SARS-CoV-2 infection has been of unprecedented
clinical and socio-economic worldwide relevance. The case fatality rate for COVID-19 grows …

Aging‐related cell type‐specific pathophysiologic immune responses that exacerbate disease severity in aged COVID‐19 patients

Y Hou, Y Zhou, L Jehi, Y Luo, MU Gack, TA Chan… - Aging …, 2022 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is especially severe in aged patients,
defined as 65 years or older, for reasons that are currently unknown. To investigate the …

[HTML][HTML] Age-related decline of de novo T cell responsiveness as a cause of COVID-19 severity

F Nicoli, MT Solis-Soto, D Paudel, P Marconi, R Gavioli… - Geroscience, 2020 - Springer
To the Editor, So far, little attention has been paid to the link between immunosenescence
and the dramatic mortality rate of coronavirus disease 2019 (COVID-19) in older age groups …

[HTML][HTML] Immune cell population and cytokine profiling suggest age dependent differences in the response to SARS-CoV-2 infection

L Aragon, A Iribarren-López, A Alberro… - Frontiers in …, 2023 - frontiersin.org
Aging population is at higher risk of developing severe COVID-19, including hospitalization
and death. In this work, to further understand the relationship between host age-related …