3D genome organization in the central nervous system, implications for neuropsychological disorders
D Sun, J Weng, Y Dong, Y Jiang - Journal of Genetics and Genomics, 2021 - Elsevier
Chromosomes in eukaryotic cell nuclei are highly compacted and finely organized into
hierarchical three-dimensional (3D) configuration. In recent years, scientists have gained …
hierarchical three-dimensional (3D) configuration. In recent years, scientists have gained …
Microduplications at the 15q11. 2 BP1–BP2 locus are enriched in patients with anorexia nervosa
Abstract Microduplication at 15q11. 2 have been reported in genetic association studies of
schizophrenia and autism. Given the potential overlap in psychiatric symptoms of …
schizophrenia and autism. Given the potential overlap in psychiatric symptoms of …
Convergent and distributed effects of the 3q29 deletion on the human neural transcriptome
Abstract The 3q29 deletion (3q29Del) confers high risk for schizophrenia and other
neurodevelopmental and psychiatric disorders. However, no single gene in this interval is …
neurodevelopmental and psychiatric disorders. However, no single gene in this interval is …
Common variants on 2p16. 1, 6p22. 1 and 10q24. 32 are associated with schizophrenia in Han Chinese population
Many schizophrenia susceptibility loci have been identified through genome-wide
association studies (GWASs) in European populations. However, until recently …
association studies (GWASs) in European populations. However, until recently …
A 200-kb region of human chromosome 22q11. 2 confers antipsychotic-responsive behavioral abnormalities in mice
Human chromosome 22q11. 2 has been implicated in various behavioral abnormalities,
including schizophrenia and other neuropsychiatric/behavioral disorders. However, the …
including schizophrenia and other neuropsychiatric/behavioral disorders. However, the …
[HTML][HTML] Quantifying the effects of 16p11. 2 copy number variants on brain structure: a multisite genetic-first study
Abstract Background 16p11. 2 breakpoint 4 to 5 copy number variants (CNVs) increase the
risk for developing autism spectrum disorder, schizophrenia, and language and cognitive …
risk for developing autism spectrum disorder, schizophrenia, and language and cognitive …
Chromosome 13q13–q14 locus overlaps mood and psychotic disorders: the relevance for redefining phenotype
The nosology of major psychoses is challenged by the findings that schizophrenia (SZ) and
bipolar disorder (BP) share several neurobiological, neuropsychological and clinical …
bipolar disorder (BP) share several neurobiological, neuropsychological and clinical …
Evidence for altered hippocampal function in a mouse model of the human 22q11. 2 microdeletion
LJ Drew, KL Stark, K Fénelon, M Karayiorgou… - Molecular and Cellular …, 2011 - Elsevier
22q11. 2 chromosomal deletions are recurrent copy number mutations that increase the risk
of schizophrenia around thirty-fold. Deletion of the orthologous chromosomal region in mice …
of schizophrenia around thirty-fold. Deletion of the orthologous chromosomal region in mice …
Dissecting 16p11. 2 hemi-deletion to study sex-specific striatal phenotypes of neurodevelopmental disorders
Neurodevelopmental disorders (NDDs) are polygenic in nature and copy number variants
(CNVs) are ideal candidates to study the nature of this polygenic risk. The disruption of …
(CNVs) are ideal candidates to study the nature of this polygenic risk. The disruption of …
1q21. 1 distal copy number variants are associated with cerebral and cognitive alterations in humans
Abstract Low-frequency 1q21. 1 distal deletion and duplication copy number variant (CNV)
carriers are predisposed to multiple neurodevelopmental disorders, including …
carriers are predisposed to multiple neurodevelopmental disorders, including …