Background The 16p11. 2 microduplication is a rare form of chromosomal rearrangement
that confers risk of multiple neuropsychiatric conditions including, schizophrenia, autism …

Importance Recurrent microdeletions and duplications in the genomic region 15q11. 2
between breakpoints 1 (BP1) and 2 (BP2) are associated with neurodevelopmental …

The psychiatric disorders autism and schizophrenia have a strong genetic component, and
copy number variants (CNVs) are firmly implicated. Recurrent deletions and duplications of …

Standard methods for the creation of neuronal cells via direct induction from primary tissue
use perinatal fibroblasts, which hinders the important study of patient specific genetic lesions …

Reciprocal chromosomal rearrangements at the 22q11. 2 locus are associated with elevated
risk of neurodevelopmental disorders. The 22q11. 2 deletion confers the highest known …

Objective: Chromosome 22q11. 2 deletion syndrome (22q11. 2DS) is associated with a
more than 20-fold increased risk for developing schizophrenia. The aim of this study was to …

Current models on the etiology of psychiatric disorders support the idea of a biologic cause
as well as interactions of biologic systems with the environment. The elucidation of the …

Chromosome 22q11. 2 Deletion Syndrome (22q11DS) is a disease caused by
microdeletions in the chromosome 22q11. 2 region, the most common interstitial deletion in …

With an incidence of 1 in 3000 live births, 22q11. 2 deletion syndrome (22q11. 2DS) is the
most common chromosomal microdeletion disorder in humans. The phenotype is …

Background As schizophrenia is highly heritable, genetic risk factors remain an attractive
avenue for furthering our understanding of its pathophysiology. Deletion of a region of …