慢性应激抑郁模型大鼠强迫游泳后海马中c-fos 的表达
马慧， 丁宝坤， 谢守付， 秦晓松， 彭淼， 金魁和 - 中国神经精神疾病杂志, 2003 - cqvip.com
目的研究慢性应激对强迫游泳大鼠海马神经元c-fos 表达的影响. 方法采用特异性抗体的免疫
组织化学方法, 在大鼠慢性应激抑郁模型基础上, 观察急性强迫游泳应激后海马神经元c-fos …
组织化学方法, 在大鼠慢性应激抑郁模型基础上, 观察急性强迫游泳应激后海马神经元c-fos …
抑郁症动物模型的研究进展
苗茸茸， 曲显俊 - 实验动物科学, 2019 - sydwkx.com
近年来, 抑郁症的发病率不断上升, 但是抑郁症的病理生理学机制仍有许多未知之处.
抑郁动物模型可以模拟人类抑郁症的临床症状且这些症状可被有效的药物逆转 …
抑郁动物模型可以模拟人类抑郁症的临床症状且这些症状可被有效的药物逆转 …
Translating the evidence for gene association with depression into mouse models of depression-relevant behaviour: current limitations and future potential
Depression is characterised by high prevalence and complex, heterogeneous
psychopathology. At the level of aetio-pathology, considerable research effort has been …
psychopathology. At the level of aetio-pathology, considerable research effort has been …
Approach to depressogenic genes from genetic analyses of animal models
T Yoshikawa - Seishin Shinkeigaku Zasshi= Psychiatria et …, 2004 - europepmc.org
Human depression or mood disorder is defined as a complex disease, making positional
cloning of susceptibility genes a formidable task. We have undertaken genetic analyses of …
cloning of susceptibility genes a formidable task. We have undertaken genetic analyses of …
抑郁症发病机制的免疫学研究进展
李红， 毛叶萌 - 中国免疫学杂志, 2016 - cqvip.com
抑郁症是由多种因素综合作用引发具有遗传倾向的慢性心理疾病, 全球患病率12%~ 17%[1],
复发率较高, 严重妨碍人们的日常生活. 抑郁症主要表现为抑郁心境, 兴趣丧失 …
复发率较高, 严重妨碍人们的日常生活. 抑郁症主要表现为抑郁心境, 兴趣丧失 …
[DOC][DOC] Submit to BMC Psychiatry mRNA and microRNA profiles in the amygdala are relevant to Susceptible and Resilient mice induced by psychological stress
J Sun, Y Lu, J Yang, Z Song, W Lu, JH Wang - assets.researchsquare.com
Background: Severe or prolonged stress increases the risk to develop psychopathologies.
An individual's perception of stress exposure varies greatly, as do its consequences …
An individual's perception of stress exposure varies greatly, as do its consequences …
抑郁症的病理生理学基础及动物模型研究进展
张阔， 杨静玉， 吴春福 - 神经药理学报, 2017 - actanp.hebeinu.edu.cn
抑郁症是严重威胁人类健康的精神情感性障碍. 迄今为止, 抑郁症的病因与发病机制尚不明确.
该文从抑郁症的病理生理学因素及常用抑郁症动物模型的角度进行综述. 通过多种动物模型对 …
该文从抑郁症的病理生理学因素及常用抑郁症动物模型的角度进行综述. 通过多种动物模型对 …
[HTML][HTML] microRNA and mRNA profiles in ventral tegmental area relevant to stress-induced depression and resilience
X Sun, Z Song, Y Si, JH Wang - Progress in Neuro-Psychopharmacology …, 2018 - Elsevier
Chronic stress with lack of reward presumably may impair brain reward circuit, leading to
major depressive disorder (MDD). Most individuals experiencing chronic stress do not suffer …
major depressive disorder (MDD). Most individuals experiencing chronic stress do not suffer …
Characterization of a novel gene-environment-based animal model to study resilience and susceptibility to PTSD and co-morbid depression
LP Iglesias, AA Coelho, NR da Silva, HK Müller… - bioRxiv, 2022 - biorxiv.org
ABSTRACT BACKGROUND Post-traumatic stress disorder (PTSD) and co-morbid
depression are frequently associated with severe symptoms, poor response to treatment and …
depression are frequently associated with severe symptoms, poor response to treatment and …
早期应激对抑郁相关行为及神经内分泌反应的长期影响
王玮文， 邵枫， 刘美， 林文娟 - 2006 - ir.psych.ac.cn
摘要临床研究发现, 早期创伤性经历是导致成年抑郁症易感性增加的高风险因素之一.
但早期应激通过何种途径对抑郁发病产生长期的影响, 目前尚不清楚. 本文综述了近年来有关的 …
但早期应激通过何种途径对抑郁发病产生长期的影响, 目前尚不清楚. 本文综述了近年来有关的 …