Purinergic P2X7 receptors may affect neuronal cell death through their ability to regulate the
processing and release of interleukin-1β (IL-1β), a key mediator in neurodegeneration. The …

The P2X7 purinergic receptor is a ligand‐gated cation channel expressed on leukocytes
including microglia. This study aimed to determine if P2X7 activation induces the uptake of …

We examined the effect of 2′-3′-O-(4-benzoylbenzoyl)-adenosine-5′-triphosphate (Bz-
ATP), a P2X7 receptor agonist, on action potential-independent glutamate release from …

ATP is a (co) transmitter and signaling molecule in the CNS. It acts at a multitude of ligand-
gated cationic channels termed P2X to induce rapid depolarization of the cell membrane …

It is well known that ATP acts as a classic neurotransmitter in the central nervous system. It is
stored in synaptic vesicles, released upon neuronal excitation, and activates both ion …

Abstract The P2X4 receptor (P2X4) is an ATP-gated cation channel that is highly permeable
to Ca 2+ and widely expressed in neuronal and glial cell types throughout the central …

ATP is an important neuronal and astroglial signaling molecule in the brain. In the present
study, brain slices were prepared from the prefrontal cortex (PFC) of Wistar rats and 2 lines …

Neural differentiation has been extensively studied in vitro in a model termed neurospheres,
which consists of aggregates of neural progenitor cells. Previous studies suggest that they …

Extracellular aggregates of amyloid β (Aβ) peptides, which are characteristic of Alzheimer's
disease (AD), act as an essential trigger for glial cell activation and the release of ATP …

P2X7 is a commonly expressed purinergic receptor, which functions as a cation-permeable
channel in the plasma membrane. In certain circumstances, the receptor may also form a …