A large body of evidence suggests the involvement of the ATP-gated purinergic receptor
P2X7 (P2X7R) in neurodegenerative diseases, including Alzheimer's disease. While it is …

Activation of the ATP-gated P2X7 receptor (P2X7R), implicated in numerous diseases of the
brain, can trigger diverse responses such as the release of pro-inflammatory cytokines …

The P2X7 receptor is a cation channel activated by high concentrations of adenosine
triphosphate (ATP). Upon long-term activation, it complexes with membrane proteins forming …

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease characterized by
a progressive cognitive decline associated with global brain damage. Initially, intracellular …

Purinergic receptors play important roles in central nervous system (CNS), where the bulk of
these receptors are implicated in neuroinflammatory responses and regulation of cellular …

Alzheimer's disease (AD) is a major cause of age-related dementia, which is becoming a
global health crisis. However, the pathogenesis and etiology of AD are still not fully …

The P2X7 receptor (P2X7R), a non-selective cation channel modulated by adenosine
triphosphate (ATP), localizes to microglia, astrocytes, oligodendrocytes, and neurons in the …

Purinergic signalling in the brain is becoming an important focus in the study of CNS health
and disease. Various purinergic receptors are found to be present in different brain cells in …

The expression of the purinergic receptor subtype P2X7R, a nonselective cationic channel
activated by high levels of adenosine triphosphate (ATP), has been studied in adult …

Recently, one of the P2 purinergic receptors, the P2X 7 receptor, has been extensively
studied in nervous system and important functions have been revealed in both astrocytes …