Identifying the signaling mechanisms that regulate adult neurogenesis is essential to
understanding how the brain may respond to neuro-inflammatory events. P2X7 receptors …

Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus.
Granular neurons generated from resident pools of stem or progenitor cells provide a …

During early human neurogenesis there is overproduction of neuroblasts and neurons
accompanied by widespread programmed cell death (PCD). While it is understood that …

J. Neurochem.(2009) 109, 846–857. Abstract Neural progenitor cells (NPCs) are capable of
self‐renewal and differentiation into neurons, astrocytes and oligodendrocytes, and have …

Activation of the ATP-gated P2X7 receptor (P2X7R), implicated in numerous diseases of the
brain, can trigger diverse responses such as the release of pro-inflammatory cytokines …

P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the
extensive release of ATP induces sustained P2X7 receptor activation, culminating in …

A large body of evidence suggests the involvement of the ATP-gated purinergic receptor
P2X7 (P2X7R) in neurodegenerative diseases, including Alzheimer's disease. While it is …

ATP, via purinergic P2X receptors, acts as a neurotransmitter and modulator in both the
central and peripheral nervous systems, and is also involved in many biological processes …

Microglial activation is an integral part of neuroinflammation associated with many
neurodegenerative conditions. Interestingly, a number of neurodegenerative conditions …

The purinergic system is one of the oldest cell-to-cell communication mechanisms and
exhibits relevant functions in the regulation of the central nervous system (CNS) …