Psychiatric diagnoses are valuable for clinical communication and decision making but have
proved less useful as entry points for unraveling the biological bases of mental disorders …

Psychiatric genetics has made substantial progress in the last decade, providing new
insights into the genetic etiology of psychiatric disorders, and paving the way for precision …

The subjective and symptomatic basis of psychiatric diagnoses—coupled with high rates of
comorbidity, clinical heterogeneity, and the overwhelming complexity of the human brain …

Psychiatric genetics is in the midst of a profound transformation. For decades, the primary
challenge for the field was simply the reliable identification of risk genes. Now, for multiple …

For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …

The reputation of the field of psychiatric genetics has recently become tarnished in the view
of many human geneticists. Too many linked loci were claimed and withdrawn, too many …

The past years have been an incredibly exciting time in the field of psychiatric genetics.
Technological and methodological advances, coupled with significant increases in sample …

It is now commonly accepted that genes contribute to the etiology of many psychiatric
disorders. Estimates of the heritability for schizophrenia have been as high as 81%, 1 for …

The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of
psychiatry. This global effort is dedicated to rapid progress and open science, and in the …

Imagine, in 1968, a 56-year-old woman presenting to her primary care physician with a
progressively worsening cough. Unrelatedly (in her mind)—and ominously (in her …